Giovanni Mirabella

11 mai 2012

La Sapienzia, Rome, & IRCSS Neuromed, Pozzilli, Italy

Why does not an inhibitory area exist ? ERPs recorded from intracranial electrodes reveal that premotor and motor cortices play a key role in stopping initiated responses

invité par Andrea Brovelli

Recent findings seem to indicate that the same regions that mediate voluntary decisions to move appear to be involved in voluntary decisions to refrain from acting. Previously we demonstrated the existence of neurons in the dorsal PMA which exhibited a pattern of activity compatible with the control of reaching arm movement initiation and suppression in monkeys (Mirabella et al, 2011). Now by recording from the surface of the fronto-temporal cortex of pharmaco-resistant epileptic patients, performing an arm reaching version of the countermanding task, we found that when a movement is successfully cancelled, an ERP complex, whose onset precedes the end of the stop process, is selectively expressed in M1, PMA and BA9. Clearly, we cannot exclude that other areas could be involved in the inhibitory processes, as ERPs reflect only phase-locked activity and primarily at very low frequencies. Nevertheless, our finding seems to indicate that these areas are the locations where the final decision as to whether or not a planned arm movement is carried out is taken.
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