Céline Amiez

25 mars 2016

Stem-cell and Brain Research Institute, INSERM U846, Bron

Functional gradients in the human prefrontal cortex can be predicted from individual sulci morphology

invitée par Olivier Coulon


It is well known that the prefrontal cortex is involved in the coordination and expression of executive functions (such as monitoring of information within working memory, performance monitoring, selection of appropriate responses, etc...). The majority of neuroimaging studies using group averaging techniques have failed to dissociate the relative contribution of each areas of the prefrontal cortex in these processes. My research uses an approach combining functional magnetic resonance imaging and subject by subject analysis. I will present data that shows 1) that individual sulci variability is a powerful tool to assess anatomo-functional dissociations between the prefrontal areas and 2) the existence of a rostrocaudal functional gradient within both the lateral and medial prefrontal cortex that can be observed in individual brains.


I did my PhD from 1999 to 2002 with Jean Paul Joseph (INSERM U371, Bron). My PhD aimed to assess the role of anterior cingulate cortex and orbitofrontal cortex in reward-based decision-making processes in behaving monkeys using electrophysiology. Then, from 2003 to 2010, I was in Michael Petrides’ lab (MNI, McGill, Canada) as a postdoc and then a research associate. During that period, I performed several fMRI studies to assess the anatomo-functional organization in the human frontal cortex. I came back to France in Stem cell and Brain Research Institute/INSERM U846 in 2010 thanks to a Neurodis Foundation grant and I got a CR1 position at CNRS in 2013.

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