version française


Basal Ganglia, Motivation and Reward

Our team uses a translational approach from rodents and monkeys to Parkinsonian patients to better understand the role of basal ganglia (BG) in motivation and reward-related processes, both in normal and dysregulated behaviors, such as addiction or impulse control disorders.

We are studying the effect of the subthalamic nucleus (STN) inactivation, using deep brain stimulation (DBS) on cocaine addiction in rodents, as well as the role of this structure in reward-related processes and in impulse control.

The research conducted in non-human primates addresses the role of BG in reinforcement learning and the neural basis of motivational processes, using electrophysiological recordings in awake animals.

The clinical approach uses combined behavioral and electrophysiological studies. We are performing electrophysiological recordings of STN activity as well as functional imaging in post-operative PD patients and studying the clinical effects of STN DBS on the motivational state of PD patients with or without impulse control disorders.

Our multi-species approach, using comparable tasks, will allow us to improve our understanding of the role of BG in motivational processes using complementary experimental techniques in normal animals, animal models of pathologies and patients.

Team manager

BAUNEZ Christelle

chef d'équipe-Team leader

Team member

Selected publications

  • Bentefour Y., Bennis M., Garcia R., and Ba-M'hamed S. (2018). High-frequency stimulation of the infralimbic cortex, following behavioral suppression of PTSD-like symptoms, prevents symptom relapse in mice. Brain Stimulation, 11: 913-920.

  • Montanari C., Giorla E., Pelloux Y., and Baunez C. (2018). Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalization playback in rats. Addiction Biology.

  • Nougaret S. and Ravel S. (2018). Dynamic Encoding of Effort and Reward throughout the Execution of Action by External Globus Pallidus Neurons in Monkeys. Journal of Cognitive Neuroscience, 30: 1130-1144.

  • Pautrat A., Rolland M., Barthelemy M., Baunez C., Sinniger V., Piallat B., Savasta M., Overton P.G., David O., and Coizet V. (2018). Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing. eLife, 7.

  • Pelloux Y., Degoulet M., Tiran-Cappello A., Cohen C., Lardeux S., George O., Koob G.F., Ahmed S.H., and Baunez C. (2018). Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Molecular Psychiatry, 23: 2266-2276.

  • Brovelli A., Badier J.-M., Bonini F., Bartolomei F., Coulon O., and Auzias G. (2017). Dynamic Reconfiguration of Visuomotor-Related Functional Connectivity Networks. The Journal of Neuroscience, 37: 839-853.

  • Marche K. and Apicella P. (2017). Changes in activity of fast-spiking interneurons of the monkey striatum during reaching at a visual target. Journal of Neurophysiology, 117: 65-78.

  • Wade C.L., Kallupi M., Hernandez D.O., Breysse E., de Guglielmo G., Crawford E., Koob G.F., Schweitzer P., Baunez C., and George O. (2017). High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology, 42: 1850-1859.

  • Degoulet M., Stelly C.E., Ahn K.-C., and Morikawa H. (2016). L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory. Molecular Psychiatry, 21: 394-402.

  • Zénon A., Duclos Y., Carron R., Witjas T., Baunez C., Régis J., Azulay J.-P., Brown P., and Eusebio A. (2016). The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making. Brain, 139: 1830-1843.
  • Publications

    CNRS logo université Aix Marseille logo | Sitemap | Terms & Conditions | contact | admin | intranet | intcloud |