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Plasticity and Physio-pathology of rhythmics Motor networks

Publications P3M


  • Aoki S., Smith J.B., Li H., Yan X., Igarashi M., Coulon P., Wickens J.R., Ruigrok T.J.H., and Jin X. (2019). An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway. eLife, 8.

  • Brocard F. (2019). New channel lineup in spinal circuits governing locomotion. Current Opinion in Physiology, 8: 14-22.

  • Canu M.-H., Fourneau J., Coq J.-O., Dannhoffer L., Cieniewski-Bernard C., Stevens L., Bastide B., and Dupont E. (2019). Interplay between hypoactivity, muscle properties and motor command: How to escape the vicious deconditioning circle? Annals of Physical and Rehabilitation Medicine, 62: 122-127.

  • Watson T.C., Obiang P., Torres-Herraez A., Watilliaux A., Coulon P., Rochefort C., and Rondi-Reig L. (2019). Anatomical and physiological foundations of cerebello-hippocampal interaction. eLife, 8.


  • Alliance E.P. and R.M.B. (2018). White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 10. Science and research in PRM: specificities and challenges. European Journal of Physical and Rehabilitation Medicine.

  • Bos R., Harris-Warrick R.M., Brocard C., Demianenko L.E., Manuel M., Zytnicki D., Korogod S.M., and Brocard F. (2018). Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion. Cell Reports, 22: 3315-3327.

  • Delcour M., Massicotte V.S., Russier M., Bras H., Peyronnet J., Canu M.-H., Cayetanot F., Barbe M.F., and Coq J.-O. (2018). Early movement restriction leads to enduring disorders in muscle and locomotion: Enduring impact of sensorimotor restriction. Brain Pathology.

  • Khalki L., Sadlaoud K., Lerond J., Coq J.-O., Brezun J.-M., Vinay L., Coulon P., and Bras H. (2018). Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats. Experimental Neurology, 299: 1-14.

  • Tsuji M., Coq J.-O., Ogawa Y., Yamamoto Y., and Ohshima M. (2018). A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis. Journal of Visualized Experiments.


  • Benammi H., Erazi H., El Hiba O., Vinay L., Bras H., Viemari J.-C., and Gamrani H. (2017). Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I. PLOS ONE, 12: e0172715.

  • Liabeuf S., Stuhl-Gourmand L., Gackière F., Mancuso R., Sanchez-Brualla I., Marino P., Brocard F., and Vinay L. (2017). Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury. Journal of Neurotrauma.

  • Plantier V. and Brocard F. (2017). Une nouvelle cible thérapeutique dans le traitement de la spasticité après une lésion de la moelle épinière : la calpaïne. médecine/sciences, 33: 629-636.

  • Sánchez-Brualla I., Boulenguez P., Brocard C., Liabeuf S., Viallat-Lieutaud A., Navarro X., Udina E., and Brocard F. (2017). Activation of 5-HT 2A receptors restores KCC2 function and reduces neuropathic pain after spinal cord injury. Neuroscience.


  • Brocard C., Plantier V., Boulenguez P., Liabeuf S., Bouhadfane M., Viallat-Lieutaud A., Vinay L., and Brocard F. (2016). Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury. Nature Medicine, 22: 404 - 411.

  • Coq J.-O., Delcour M., Massicotte V.S., Baud O., and Barbe M.F. (2016). Prenatal ischemia deteriorates white matter, brain organization, and function: implications for prematurity and cerebral palsy. Developmental Medicine & Child Neurology, 58: 7-11.

  • Doyon N., Vinay L., Prescott S. A., and De Koninck Y. (2016). Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition. Neuron, 89: 1157-1172.

  • Lambert F.M., Bras H., Cardoit L., Vinay L., Coulon P., and Glover J.C. (2016). Early postnatal maturation in vestibulospinal pathways involved in neck and forelimb motor control: Vestibulospinal Projections to Cervical Spinal Cord in Neonatal Mouse. Developmental Neurobiology, 76: 1061-1077.

  • Ohshima M., Coq J.-O., Otani K., Hattori Y., Ogawa Y., Sato Y., Harada-Shiba M., Ihara M., and Tsuji M. (2016). Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity. Scientific Reports, 6: 39377.

  • Ruigrok T.J.H., van Touw S., and Coulon P. (2016). Caveats in Transneuronal Tracing with Unmodified Rabies Virus: An Evaluation of Aberrant Results Using a Nearly Perfect Tracing Technique. Frontiers in Neural Circuits, 10.

  • Tree K., Viemari J.C., Cayetanot F., and Peyronnet J. (2016). Growth restriction induced by chronic prenatal hypoxia affects breathing rhythm and its pontine catecholaminergic modulation. Journal of Neurophysiology, 116: 1654-1662.


  • Bentefour Y., Bennis M., Garcia R., and M’hamed S.B. (2015). Effects of paroxetine on PTSD-like symptoms in mice. Psychopharmacology, 232: 2303-2312.

  • Bouhadfane M., Kaszás A., Rózsa B., Harris-Warrick R.M., Vinay L., and Brocard F. (2015). Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin. eLife, 4: 19.

  • Cazals Y., Bévengut M., Zanella S., Brocard F., Barhanin J., and Gestreau C. (2015). KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing. Nature Communications, 6: 8780.

  • Deng Y., Lanciego J., Goff L.K.-L., Coulon P., Salin P., Kachidian P., Lei W., Del Mar N., and Reiner A. (2015). Differential organization of cortical inputs to striatal projection neurons of the matrix compartment in rats. Frontiers in Systems Neuroscience, 9: 51.

  • Durand J., Filipchuk A., Pambo-Pambo A., Amendola J., Borisovna Kulagina I., and Guéritaud J.-P. (2015). Developing electrical properties of postnatal mouse lumbar motoneurons. Frontiers in Cellular Neuroscience, 9.

  • Kasumacic N., Lambert F.M., Coulon P., Bras H., Vinay L., Perreault M.-C., and Glover J.C. (2015). Segmental Organization of Vestibulospinal Inputs to Spinal Interneurons Mediating Crossed Activation of Thoracolumbar Motoneurons in the Neonatal Mouse. Journal of Neuroscience, 35: 8158-8169.

  • Kerzoncuf M., Bensoussan L., Delarque A., Durand J., Viton J., and Rossi-Durand C. (2015). Plastic changes in spinal synaptic transmission following botulinum toxin A in patients with post-stroke spasticity. Journal of Rehabilitation Medicine, 47: 910-916.

  • Soussi R., Boulland J.-L., Bassot E., Bras H., Coulon P., Chaudhry F.A., Storm-Mathisen J., Ferhat L., and Esclapez M. (2015). Reorganization of supramammillary–hippocampal pathways in the rat pilocarpine model of temporal lobe epilepsy: evidence for axon terminal sprouting. Brain Structure and Function, 220: 2449-2468.


  • Bellot B., Peyronnet-Roux J., Gire C., Simeoni U., Vinay L., and Viemari J.-C. (2014). Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice. Pediatric Research, 75: 723-730.

  • Gackière F. and Vinay L. (2014). Serotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cord. Frontiers in Neural Circuits, 8.

  • Schmied A., Forget R., and Vedel J.-P. (2014). Motor unit firing pattern, synchrony and coherence in a deafferented patient. Frontiers in Human Neuroscience, 8.

  • Tree K.C., Scotto di Perretolo M., Peyronnet J., and Cayetanot F. (2014). In utero cannabinoid exposure alters breathing and the response to hypoxia in newborn mice. The European Journal of Neuroscience, 40: 2196-2204.


  • Bos R., Sadlaoud K., Boulenguez P., Buttigieg D., Liabeuf S., Brocard C., Haase G., Bras H., and Vinay L. (2013). Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2. Proceedings of the National Academy of Sciences of the United States of America, 110: 348-353.

  • Bouhadfane M., Tazerart S., Moqrich A., Vinay L., and Brocard F. (2013). Sodium-Mediated Plateau Potentials in Lumbar Motoneurons of Neonatal Rats. Journal of Neuroscience, 33: 15626-15641.

  • Brocard F., Shevtsova N. A., Bouhadfane M., Tazerart S., Heinemann U., Rybak I. A., and Vinay L. (2013). Activity-Dependent Changes in Extracellular Ca2+ and K+ Reveal Pacemakers in the Spinal Locomotor-Related Network. Neuron, 77: 1047-1054.

  • Carroll M.S., Viemari J.-C., and Ramirez J.-M. (2013). Patterns of inspiratory phase-dependent activity in the in vitro respiratory network. Journal of Neurophysiology, 109: 285-295.

  • Khalki L., Ba M'hamed S., Sokar Z., Bennis M., Vinay L., Bras H., and Viemari J.-C. (2013). Prenatal exposure to fenugreek impairs sensorimotor development and the operation of spinal cord networks in mice. PloS one, 8.

  • Viemari J.-C., Garcia A.J., 3rd, Doi A., Elsen G., and Ramirez J.-M. (2013). β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Frontiers in neural circuits, 7.

  • Viemari J.-C., Menuet C., and Hilaire G. (2013). [Electrophysiological, molecular and genetic identifications of the pre-Bötzinger complex]. Médecine sciences: M/S, 29: 875-882.


  • Ben-Ari Y., Woodin M.A., Sernagor E., Cancedda L., Vinay L., Rivera C., Legendre P., Luhmann H.J., Bordey A., Wenner P., Fukuda A., van den Pol A.N., Gaiarsa J.-L., and Cherubini E. (2012). Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!. Frontiers in Cellular Neuroscience, 6.

  • Bensoussan L., Duclos Y., and Rossi-Durand C. (2012). Modulation of human motoneuron activity by a mental arithmetic task. Human Movement Science, 31: 999-1013.

  • Bos R. and Vinay L. (2012). Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro. Journal of Neurophysiology, 107: 3107-3115.

  • Crone S.A., Viemari J.-C., Droho S., Mrejeru A., Ramirez J.-M., and Sharma K. (2012). Irregular Breathing in Mice following Genetic Ablation of V2a Neurons. Journal of Neuroscience, 32: 7895-7906.

  • Dehorter N., Vinay L., Hammond C., and Ben-Ari Y. (2012). Timing of developmental sequences in different brain structures: physiological and pathological implications. European Journal of Neuroscience, 35: 1846-1856.

  • Filipchuk A.A. and Durand J. (2012). Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis. Neuroscience, 209: 144-154.

  • Kakinohana O., Hefferan M.P., Miyanohara A., Nejime T., Marsala S., Juhas S., Juhasova J., Motlik J., Kucharova K., Strnadel J., Platoshyn O., Lazar P., Galik J., Vinay L., and Marsala M. (2012). Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity. PLoS ONE, 7.

  • Suzuki L., Coulon P., Sabel-Goedknegt E.H., and Ruigrok T.J.H. (2012). Organization of Cerebral Projections to Identified Cerebellar Zones in the Posterior Cerebellum of the Rat. The Journal of Neuroscience, 32: 10854-10869.
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