Peter Brown

29 juin 2012

Dept. Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK

Excessive synchrony in Parkinson’s disease and its implications for therapeutic brain stimulation

invité par Alexandre Eusebio


There is growing interest in how synchronised activity across populations of neurons might underlie impairment in some diseases and there is now a general consensus that exaggerated oscillatory synchrony occurs within and between the basal ganglia and cerebral cortex in patients with Parkinson’s disease. In particular, activity in the beta frequency band (13-30 Hz) is prominent, and can be attenuated by treatment with dopaminergic drugs. The latter suggests that elevated beta activity may be a key disturbance in Parkinson’s disease (PD). Here, I will consider both correlative evidence and tests of causality that support a mechanistic link between pathologically exaggerated beta activity and stiffness and slowness of movement in PD. Questions, however, remain with regards to the quantitative importance of beta and the role of this activity under physiological circumstances. In particular, recent studies suggest that the modulation of beta activity may play a part in both motor and cognitive domains. Finally, I will suggest how our new understanding of circuit-level disturbances in PD may provide a basis for the development of more sophisticated forms of therapeutic stimulation for Parkinson’s disease, such as those using closed loop feedback control and specific temporal patterning.
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