Matteo Carandini

23 juin 2016

SEMINAIRE TUTORE

Cortical Processing Lab, UCL, London, UK

From vision to decision and navigation in mouse cortex

invité par le PhD program (Frédéric Chavane)


Abstract : As signals progress along the early visual system, they undergo a remarkable transformation. Before reaching the primary visual cortex (V1) responses are still highly repeatable, and they can be predicted by simple model of image processing. In V1, instead, responses become hugely affected by activity that originates within the brain, which varies from trial to trial, and is closely related to behavior. For instance, a major factor that controls responses of neurons in the mouse visual cortex is locomotion. In mouse V1, locomotion changes the nature of spatial integration, reducing the strength of lateral interactions. Moreover, locomotion interacts with vision to affect responses during navigation, perhaps to help the animal estimate is own movement. In the parietal visual areas that follow V1, the visual signals are transformed to encode variables relevant to navigation. We study this transformation by training mice to make visual decisions while they navigate in a virtual reality environment. Preliminary results indicate that these neurons code for combinations of the animal’s heading and position in the room. The activity of neurons in parietal cortex of the mouse thus reflects the interactions of vision, decision, and navigation.

References : Sato, Haider, Häusser, Carandini (in press) An excitatory basis for divisive normalization in visual cortex. Nature Neurosci Carandini M, Heeger DJ (2012) Normalization as a canonical neural computation. Nature Rev Neurosci 13 : 51-62

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