Juliane Britz/Annulé

20 juin 2014

Functional Brain Mapping Lab, Centre Médical Universitaire, Geneve, Suisse

Building blocks of consciousness – EEG microstates and their relationship to consciousness

invitée par Bruno Wicker

The EEG topography is a global measure of the momentary brain state, and its configuration remains stable for brief periods ( 70 – 100 ms), the so- called EEG microstates. One characteristic feature of EEG microstates is the rapid transition from one stable scalp field topography into another. Their temporal dynamics and local syntax are altered in different neurological and psychiatric conditions, and they are malleable by psychotropic drugs, which lead to the hypothesis that they constitute the “basic building blocks of cognition” or “atoms of thought” underlying spontaneous conscious cognitive activity. I will report data using two complementary approaches using EEG microstates to assess correlates of consciousness. One approach assesses how the momentary brain state indexed by the pre-stimulus microstate determines differences in perceptual awareness for physically identical stimuli such as perceptual reversals of ambiguous figures and during binocular rivalry and the emergence of awareness of near-threshold stimuli. The other approach assesses how the intrinsic spatio-temporal dynamics of the EEG microstate sequences can be related to differences in consciousness. Using simultaneous EEG/fMRI, we identified EEG microstates as the electrophysiological correlate of four fMRI resting state networks, this link could be established because the EEG microstates are mono-fractal and show scale-free properties from tenths of seconds to tens of seconds. Their sequence is neither random nor determined but chaotic : it follows clearly defined rules without being predictable, analogous to how all natural languages follow a generative grammar. This is the key feature that permits the brain to rapidly adjust to unexpected events and to successfully interact with the environment, which can be considered as a necessary prerequisite for consciousness. This property changes with changes of consciousness during anesthesia in humans and monkeys.

References :

Britz J, Landis T, Michel CM. (2009) Right parietal brain activity precedes perceptual alternation of bistable stimuli. Cerebral Cortex, 19(1), 55-65

Britz J, Pitts MA, Michel CM. (2011) Right parietal brain activity precedes perceptual alternations during binocular rivalry, Human Brain Mapping, 32, 1432-1442.

Pitts MA, Britz J. (2011) Insights from intermittent binocular rivalry and EEG. Frontiers in Human Neuroscience,5 Special Topic "Binocular rivalry : a gateway to consciousness"

Britz J, van de Ville D, Michel CM. (2010) BOLD correlates of EEG topography reveal rapid resting-state dynamics, NeuroImage, 52(4), 1162-1170

Van de Ville D, Britz J, Michel CM. (2010) EEG microstate sequences in healthy humans at rest reveal scale-free dynamics, Proceedings of the National Academy of Sciences, USA 107(42):18179-84

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