Claire Wyart

29 janvier 2016

Institut du Cerveau et de la Moelle Epinière (ICM), Team “Probing dynamic sensory-motor integration in spinal circuits”, Paris

Investigation of a novel sensory interface relaying information from the cerebrospinal fluid to motor circuit

invitée par Jean-Charles Viemari

Abstract : The cerebrospinal fluid (CSF) is a complex solution flowing around the brain and spinal cord. Behavior has long been known to be influenced by the content and flow of the CSF, but the underlying mechanisms are completely unknown. CSF-contacting neurons by their location at the interface with the CSF are in ideal position to sense CSF cues and to relay information to the nervous system. By combining electrophysiology, optogenetics, bioluminescence monitoring with calcium imaging in vivo, we demonstrate that neurons contacting the CSF in the spinal cord detect local bending and in turn feed back GABAergic inhibition to multiple interneurons driving locomotion in the ventral spinal cord. Behaviour analysis of animals deprived of this mechano-sensory pathway reveals its contribution in modulating frequency of locomotion. Altogether our approach developed in a transparent animal model shed light on a novel pathway enabling sensory motor integration between the CSF and motor circuits confined to the spinal cord

CNRS logo université Aix Marseille logo | plan du site | mentions légales | contact | admin | intranet | intcloud |