Christophe Mulle

24 novembre 2017


CNRS UMR 5297, Interdisciplinary Institute of Neuroscience, University of Bordeaux

Synaptic dysfunction in models of Alzheimer’s disease

invité par le PhD program

abstract :

Rapid encoding of episodic memory is essential in our daily life. My team is interested in understanding the synaptic mechanisms of information encoding in the hippocampus in physiological conditions and in the context of Alzheimer’s disease. This process is particularly affected in disorders related to aging such as in Alzheimer’s disease and other dementia. We focus on CA3 for it is crucial to one-trial memory encoding. Computational theories propose that CA3 rapidly stores information in the CA3 autoassociative network by synaptic plasticity mechnanisms with the assistance of inputs from the dentate gyrus through the "detonator" mossy fiber synapses. The work I will present deals with short- and long term synaptic plasticity mechanisms at both these connections in mouse models of AD. Mutations in the presenilin gene account for the large majority of familial forms of AD. I will share unpublished data on the synaptic function of presenilin, the catalytic subunit of gamma-secretase, which opens new perspectives for understanding synaptic dysfunction in the AD brain.

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