Christian Montanari

27 mai 2016


Institut de Neurosciences de la Timone, CNRS-AMU, BaGaMoRe, Marseille

Contribution of the subthalamic nucleus (STN) to the effects of negative and positive ultrasonic vocalizations (USV) playback on cocaine self-administration in rats

Abstract :

Social factors are well known to affect drug consumption in both rats and humans but little is known regarding the neurobiological basis of this influence. We have previously shown that the subthalamic nucleus is involved in both motivational and emotional processes and could thus play a role in the influence of social factor on drug intake. Ultrasonic vocalizations serve important communicative functions as socio-affective signals in rats. In fact, in aversive and appetitive situations, 22- and 50-kHz ultrasonic vocalizations are respectively emitted, most notably during social interactions. The aim of the ongoing projects I am doing is thus to investigate the subthalamic nucleus contribution on the influence of negative (22 kHz) and positive (50 kHz) ultrasonic vocalizations playback of a peer on cocaine self-administration in rats. Our preliminary results confirm the subthalamic nucleus as a crucial node where motivational and emotional processes interact to drive our behavior.

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