COQ Jacques olivier

Nom : COQ
Prénom : Jacques olivier
Téléphone : 04 91 32 40 17
Fonction : chercheur
Grade : CRCN
Bureau : xxx



NAME : J-Olivier COQ

POSITION TITLE : Senior Researcher (permanent position) at CNRS (Centre National de la Recherche Scientifique) since 2002

- 2001-02 : postdoc, UC San Francisco, USA (Pr MM Merzenich)
- 1999-00 : postdoc, Vanderbilt Univ., Nashville, USA (Pr JH Kaas)
- 1998 : PhD Neuroscience, Aix Marseille Université
- 1993 : Master 2 Neuroscience, Aix Marseille Université
- 1992 : Master 1 Cellular Biology & Physiology, University of Bordeaux 1

P3M Team in INT. The main aim of our lab is to carry out world class research in fundamental neurosciences, from cellular to cognitive levels and to bridge gaps between fundamental and clinical approaches. Our Team P3M investigates the plasticity of rhythmic motor networks (locomotion and breathing) during both development and pathological conditions (spinal cord injury, perinatal hypoxia/ischemia). Our studies scope from rodents (rats and transgenic mice) to transfer in humans (patents, RCTs, consulting activities in CROs…).

Field of interests. My work has been devoted to study the cortical and spinal plasticity in relation to 1) altered sensorimotor experience during development and in adulthood, 2) perceptive abilities, and 3) stroke and perinatal hypoxia/ischemia. Using computational tools, I also studied neural coding. My current efforts are focused to develop animal models of disorders, such as Encephalopathy of Prematurity, spasticity, Cerebral Palsy and Developmental Coordination Disorder (DCD). Our rat models are based on mild intrauterine hypoperfusion (prenatal ischemia) and/or postnatal movement restriction. Our aim is to better understand the mechanisms underlying these invalidating disorders with no satisfying cure so far and to develop new strategies of neuroprotection/prevention, remediation and early diagnosis in high-risk pregnant women. My technical expertise mainly covers cognition, behaviors, learning, locomotion and in vivo/vitro electrophysiology, ranging from intracellular patch-clamp to extracellular multi-electrode recordings.

Current collaboborations :
- Pr M-H Canu, Team APMS, UrePSSS, EA4488, Université de Lille
- Dr C Assainte et M Vogoyau, Lab Neurosciences Cognitives (LNC), UMR7291, Marseille
- Pr O Baud & P Gressens, Neuroprotection du cerveau en développement, Inserm U1141, Paris
- Pr M Tsuji, Tokyo’s Woman Univ. ; Pr Y Sato, Nagoya Univ. Hospital ; Dr T Nagamura-Inoue, The Univ. of Tokyo & Dr M Umezawa, Tokyo Univ., Japan
- Pr MB Barbe, Temple University, Philadelphia, USA
- Pr AE Toscano, Universidade Federale de Pernambuco, Recife, Brasil

Main publications.
- 48 publications (34 peer-reviewed, 14 book chapters and proceedings)
- 927 citations, H index : 18
- 29 recent invited conferences (France, Brazil, The Netherlands, Italy, Denmark, Poland, Australia, Japan, USA)
- 106 abstracts in national and international meetings

- Delcour M et al, Cayetanot F, Barbe MF, Coq JO (2018) Early movement restriction leads to maladaptive reorganization in the sensorimotor cortex and to movement disorders. Sci Rep. doi:10.1038/s41598-018-34312-y
- Delcour M, Massicotte VS, Russier M, Bras H, Peyronnet J, Canu MH, Cayetanot F, Barbe MF, Coq JO (2018) Early movement restriction leads to enduring disorders in muscle and locomotion. Brain Pathol, doi : 10.1111/bpa.12594.
- Coq JO et al. (2018) Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats : Implications for Prematurity. Front Neurol, 9:423. doi : 10.3389/fneur.2018.00423.
- Tsuji M, Coq JO et al. (2018) A rat model of mild Intrauterine hypoperfusion. Journal Vis Exp, e56723.
- Khalki L, Sadlaoud K, Lerond J, Coq JO, Brezun JM, Vinay L, Coulon P, Bras H (2018) Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats. Exp Neurol, 299:1-14.
- Ohshima M, Coq JO et al., Tsuji M (2016) Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity. Sci Rep, 39377:1-13.
- Coq JO et al. (2016) Prenatal ischemia deteriorates white matter, brain organization and function : implications for prematurity and cerebral palsy. Dev Med Child Neurol, 58 (S4):7-11.
- Coq JO, Delcour M, Massicotte VS, Barbe MF (2015) How white matter injury may contribute to the emergence of neurodevelopmental disorders in cerebral palsy ? Dev Med Child Neurol, 57 (S4):10.
- Delcour M et al., Coq JO (2012) Neuroanatomical, Sensorimotor and Cognitive Deficits in Adult Rats with White Matter Injury following Prenatal Ischemia. Brain Pathol, 22 : 1-16.
- Delcour M, Russier M, Mamta A, Baud O, Paban V, Barbe MB, Coq JO (2012) Impact of prenatal ischemia on behavior, cognitive abilities and neuroanatomy in adult rats with white matter damage. Behav Brain Res, 232 : 233-244.
- Canu MH, Coq JO, Barbe MF, Dinse HR (2012) Plasticity of adult sensorimotor system. Neural Plast, vol 2012, 768259-61 (doi:10.1155/2012/768259).
- Delcour M, Russier M, Xin D, Massicotte VS, Barbe MF, Coq JO (2011) Mild musculoskeletal and locomotor alterations in adult rats with white matter injury following prenatal ischemia. Int J Dev Neurosci, 29 : 593-607.
- Coq JO, Strata F, Russier M, Saafadi FF, Merzenich MM, Byl NN, Barbe MF (2008) Impact of neonatal asphyxia and hind limb immobilization on musculoskeletal tissues and S1 map organization : implications for cerebral palsy, Exp Neurol, 210 : 95-108.
- Blanc JL, Coq JO (2007) Coding processes involved in the cortical representation of complex tactile stimuli. J Physiol (Paris), 101 : 22-31.
- Xerri C, Bourgeon S, Coq JO (2005) Perceptual context-dependent remodeling of the forepaw map in the SI cortex of rats trained on tactile discrimination, Behav Brain Res, 162 : 207-21.
- Strata F, Coq JO, Byl N, Merzenich MM (2004) Effects of sensorimotor restriction and anoxia on gait and motor cortex organization : implications for a rodent model of cerebral palsy. Neuroscience, 129 : 141-56.
- Coq JO, Xerri C (1999) Tactile impoverishment and sensory-motor restriction deteriorate the forepaw cutaneous map in the primary somatosensory cortex of adult rats. Exp Brain Res ; 129 : 518-531.
- Coq JO, Xerri C (1999) Acute reorganization of the forepaw representation in the rat SI cortex after focal cortical injury : neuroprotective effects of piracetam treatment. Eur J Neurosci ; 11 : 2597-608.
- Coq JO, Xerri C (1998) Environmental enrichment alters organizational features of the forepaw representation in the primary somatosensory cortex of adult rats. Exp Brain Res ; 121 : 191-204.

Ongoing research supports
- 12 grants since 2001 (ANR, Fondation Paralysie Cérébrale, CP Alliance, Institut de France, Région PACA, Sandler Found…)

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