BOS Remi

Nom : BOS
Prénom : Remi
Téléphone : 04 91 32 41 31
Fonction : Chercheur
Grade : CRCN
Bureau : 2.16


After completing a first post-doc (feb. 2013-april 2016) in the Feller lab at the University of California in Berkeley (USA), I joined in 2016 the Brocard lab at the Institut des Neurosciences de la Timone (INT) in Marseille (France), where I study the plasticity of the spinal motor networks. I have been recruited as a CNRS permanent researcher since october 2018. My research focuses on the following :

1/ Neuron-Glia crosstalk in the spinal motor network. I am trying to understand how astrocytes (1) detect, (2) respond to changes and (3) modify the excitability of the lumbar neurons both in development and in certain pathological conditions (i.e. following spinal cord injury). To tackle this question, I use two-photon calcium imaging of astrocytes coupled with patch-clamp recordings of neuronal activity as well as pharmaco-genetics tools to modify the astrocytic activity and to observe the influence on (1) neuronal firing properties and (2) muscular activities (i.e. EMG recordings).

2/ Development of Motoneurons (MNs) non-linear firing properties. This project consists in determining the mechanisms underlying the development of firing properties of bistable MNs in neonatal rodents. To answer this question, I use a combination of techniques such as patch-clamp recordings of MNs activity, immunohistochemistry and in vivo recordings of muscle activities

You can find here my list of publications :

Bos R. , Harris-Warrick R.M., Brocard C., Demianenko L., Manuel M., Zytnicki D., Korogod S. and Brocard F. Kv1.2 channels promote nonlinear spiking motoneurons for powering up locomotion. Cell Reports, 2018

Bos R. , Gainer C., Feller M.B. Role for visual experience in the development of direction selective circuits. Curr. Biol, 2016

Rosa J.M.*, Bos R.*, Sack G.S., Fortuny C., Agarwal A., Bergles D.E., Flannery J.G., Feller M.B. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Elife, 2015. *these authors contributed equally to this work

Vlasits A.L., Bos R., Morrie R.D., Fortuny C., Flannery J.G., Feller M.B., Rivlin-Etzion M. Visual stimulation switches the polarity of excitatory input to starburst amacrine cells. Neuron, 2014

Bos R., Sadlaoud K., Buttigieg D., Liabeuf S., Boulenguez P., Brocard C., Haase G., Bras H., Vinay L. Activation of 5-HT2A receptors up-regulates the function of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci USA, 2013

Bos R., Vinay L. Glucose is an adequate energy substrate for the depolarizing action of GABA and glycine in the neonatal rat spinal cord in vitro. J. Neurophysiol. 2012

Bos R., Brocard F., Vinay L. Primary afferent terminals acting as excitatory interneurons contribute to spontaneous motor activities in the immature spinal cord J. Neuroscience 2011

Viemari JC, Bos R, Boulenguez P, Brocard C, Brocard F, Bras H, Coulon P, Liabeuf S, Pearlstein E, Sadlaoud K, Stil A, Tazerart S, Vinay L. Chapter 1-importance of chloride homeostasis in the operation of rhythmic motor networks. Progr. Brain. Res. 2011

Boulenguez P, Liabeuf S, Bos R, Bras H, Jean-Xavier C, Brocard C, Stil A, Darbon P, Cattaert D, Delpire E, Marsala M, Vinay L. Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nat Med. 2010

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